INDICATIONS AND USAGE（适应症）

PADCEV® is indicated for the treatment of adult patients with locally advanced or metastatic urothelial cancer (mUC) who:

have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor and platinum-containing chemotherapy, or

are ineligible for cisplatin-containing chemotherapy and have previously received one or more prior lines of therapy.

DOSAGE（服用剂量）

Recommended Dosage

The recommended dose of PADCEV is 1.25 mg/kg (up to a maximum of 125 mg for patients ≥100 kg) administered as an intravenous infusion over 30 minutes on Days 1, 8 and 15 of a 28-day cycle until disease progression or unacceptable toxicity.

ADVERSE REACTIONS（不良反应）

Skin Reactions

Hyperglycemia

Pneumonitis

Peripheral Neuropathy

Ocular Disorders

Infusion Site Extravasation

For full information, please refer to:

https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/b5631d3e-4604-4363-8f20-11dfc5a4a8ed/spl-doc?hl=Padcev

Padcevinformation