All Names： Inrebic，Fedratinib
Customs Clearance Procedure：If the customs requires the package for customs clearance, please pay the customs clearance fee according to the content of EMS SMS and customs regulations.
INDICATIONS AND USAGE
INREBIC® is indicated for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis (MF).
Conduct baseline testing of thiamine (Vitamin B1) levels prior to initiation of INREBIC.
The recommended dosage of INREBIC is 400 mg taken orally once daily for patients with a baseline platelet count of greater than or equal to 50 × 109/L.
INREBIC may be taken with or without food. Administration with a high fat meal may reduce the incidence of nausea and vomiting.
Modify the dose for patients using concomitant strong CYP3A4 inhibitors, and in patients with severe renal impairment (creatinine clearance (CLcr) 15 mL/min to 29 mL/min).
If a dose of INREBIC is missed, the next scheduled dose should be taken the following day.
Patients that are on treatment with ruxolitinib before the initiation of INREBIC must taper and discontinue according to the ruxolitinib prescribing information.
Encephalopathy, including Wernicke's
Anemia and Thrombocytopenia
Amylase and Lipase Elevation
Major Adverse Cardiac Events
For full information, please refer to:
No information yet!!!