All Names: margenza
Indications:Metastatic HER2-Positive Breast Cancer
Manufacturer:MacroGenics,USA
Customs Clearance Procedure:If the customs requires the package for customs clearance, please pay the customs clearance fee according to the content of EMS SMS and customs regulations.
INDICATIONS AND USAGE(适应症)
MARGENZA is indicated, in combination with chemotherapy, for the treatment of adult patients with metastatic HER2-positive breast cancer who have received two or more prior anti-HER2 regimens, at least one of which was for metastatic disease.
DOSAGE(服用剂量)
Recommended Doses and Schedules
The recommended dose of MARGENZA is 15 mg/kg, administered as an intravenous infusion every 3 weeks (21-day cycle) until disease progression or unacceptable toxicity.
Administer MARGENZA as an intravenous infusion at 15 mg/kg over 120 minutes for the initial dose, then over a minimum of 30 minutes every 3 weeks for all subsequent doses.
On days when both MARGENZA and chemotherapy are to be administered, MARGENZA may be administered immediately after chemotherapy completion.
Refer to the respective Prescribing Information for each therapeutic agent administered in combination with MARGENZA for the recommended dosage information, as appropriate.
ADVERSE REACTIONS(不良反应)
Left Ventricular Dysfunction
Embryo-Fetal Toxicity
Infusion-Related Reactions
For full information, please refer to:
https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/e97a5872-eabf-463b-8f4c-5b5aed9c7bf0/spl-doc?hl=margenza
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