All Names: Siltuximab,Sylvant
Indications:Multicentric Castleman's Disease (MCD)
Manufacturer:Johnson,USA
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INDICATIONS AND USAGE(适应症)
SYLVANT is indicated for the treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.
Limitations of Use
SYLVANT was not studied in patients with MCD who are HIV positive or HHV-8 positive because SYLVANT did not bind to virally produced IL-6 in a nonclinical study.
DOSAGE(服用剂量)
Administer SYLVANT 11 mg/kg over 1 hour as an intravenous infusion every 3 weeks until treatment failure.
Perform hematology laboratory tests prior to each dose of SYLVANT therapy for the first 12 months and every 3 dosing cycles thereafter.
ADVERSE REACTIONS(不良反应)
Concurrent active severe infections
Infusion-related reactions and hypersensitivity
Gastrointestinal perforation
For full information, please refer to:
https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/8d663642-f52e-49c0-a023-2da083fdfc0b/spl-doc?hl=Siltuximab
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