INDICATIONS AND USAGE（适应症）

LYSODREN is indicated for the treatment of patients with inoperable, functional or nonfunctional, adrenal cortical carcinoma.

DOSAGE（服用剂量）

The recommended initial dose of LYSODREN is 2 g to 6 g orally, in three or four divided doses per day. Increase doses incrementally to achieve a blood concentration of 14 to 20 mg/L, or as tolerated. LYSODREN is a cytotoxic drug. Follow applicable special handling and disposal procedures.

ADVERSE REACTIONS（不良反应）

Adrenal Crisis in the Setting of Shock or Severe Trauma

CNS Toxicity

Adrenal Insufficiency

Ovarian macrocysts

For full information, please refer to:

https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/f0cd76e9-460c-450e-b094-172e636f340a/spl-doc?hl=Mitotane

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