INDICATIONS AND USAGE（适应症）

COTELLIC® is indicated for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib.

DOSAGE（服用剂量）

The recommended dosage regimen of COTELLIC is 60 mg (three 20 mg tablets) orally taken once daily for the first 21 days of each 28-day cycle until disease progression or unacceptable toxicity .

Take COTELLIC with or without food.

If a dose of COTELLIC is missed or if vomiting occurs when the dose is taken, resume dosing with the next scheduled dose.

ADVERSE REACTIONS（不良反应）

New Primary Cutaneous Malignancies

Hemorrhage

Cardiomyopathy

Serious Dermatologic Reactions

Serous Retinopathy and Retinal Vein Occlusion

Hepatotoxicity

Rhabdomyolysis

Severe Photosensitivity

For full information, please refer to:

https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/c387579e-cee0-4334-bd1e-73f93ac1bde6/spl-doc?hl=Cotellic

Cotellicinformation